TABLE 10.
Effect of a New Carbapenem-Resistant Enterobacteriaceae (CRE) Definition on the Percent Resistance, by Healthcare-Associated Infection Type and Pathogen Reported to the National Healthcare Safety Network (NHSN), 2014
| CRE pathogen, CRE definition | CLABSI | CAUTI | SSI | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of isolates reported | % of isolates testedc | % Resistance | No. of isolates reported | % of isolates testedc | % Resistance | No. of isolates reported | % of isolates testedc | % Resistance | |
| Klebsiella (pneumoniae/oxytoca) | 2,200 | 4,725 | 2,319 | ||||||
| Futurea | 77.0 | 10.0 | 73.9 | 9.3 | 72.6 | 2.9 | |||
| Currentb | 73.3 | 10.9 | 68.8 | 9.5 | 66.0 | 3.3 | |||
| Escherichia coli | 1,595 | 10,840 | 6,816 | ||||||
| Futurea | 75.0 | 1.4 | 71.5 | 0.6 | 73.1 | 0.4 | |||
| Currentb | 70.9 | 1.9 | 66.6 | 1.1 | 66.8 | 0.7 | |||
| Enterobacter spp. | 1,069 | 1,641 | 2,056 | ||||||
| Futurea | 76.0 | 5.2 | 75.8 | 6.3 | 74.5 | 2.0 | |||
| Currentb | 70.7 | 6.6 | 70.7 | 6.5 | 67.3 | 3.4 | |||
| All CRE | 4,864 | 17,206 | 11,191 | ||||||
| Futurea | 76.1 | 6.2 | 72.6 | 3.6 | 73.3 | 1.2 | |||
| Currentb | 71.9 | 7.1 | 67.6 | 4.0 | 66.7 | 1.8 | |||
NOTE. CAUTI, catheter-associated urinary tract infection; CLABSI, central line–associated bloodstream infection; SSI, surgical site infection.
In future iterations of this report, the Centers for Disease Control and Prevention will use an updated definition for carbapenem-resistant Enterobacteriaceae (CRE). The future CRE definition includes any Klebsiella pneumoniae, Klebsiella oxytoca, Escherichia coli, or Enterobacter spp. that tested resistant [R] to imipenem, meropenem, doripenem, or ertapenem.
Current definition of CRE includes any Klebsiella pneumoniae, Klebsiella oxytoca, Escherichia coli, or Enterobacter spp. that tested intermediate [I] or resistant [R] to imipenem, meropenem, or doripenem.
If the percent of isolates tested is less than 70%, caution should be used when interpreting the percent resistance.