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. 2019 Nov 14;25:734–744.

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Copyright © 2019 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Decreased glutathione peroxidase 3–antisense (GPX3-AS) expression and increased human lens epithelial cell (HLEC) apoptosis are induced by H₂O₂. A: SRA01/04 cells were treated with H₂O₂ for 24 h, and the GPX3-AS levels were detected by quantitative real-time PCR (qRT-PCR). **p<0.01 versus control group. B: Cell viability was detected by Cell Counting Kit-8 (CCK-8) assay. ***p<0.001 versus control group. C: TUNEL staining of SRA01/04 cells with or without H₂O₂ treatment. Scale bar = 50 μm. D, E: Active caspase-3, Bax, and Bcl-2 expression in SRA01/04 cells was detected by western blot. *p<0.05 versus each control group. F, G: Flow cytometry analysis of H₂O₂-induced apoptosis. ***p<0.001 versus control group. n = 5 per group.