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. 2019 Nov 14;25:734–744.

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Copyright © 2019 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Glutathione peroxidase 3–antisense (GPX3-AS) inhibits H₂O₂-induced SRA01/04 cell apoptosis by upregulating GPX3. A, B: SRA01/04 cells were transfected with scramble or GPX3 siRNA, and GPX3 mRNA and GPX3-AS levels were detected by quantitative real-time PCR (qRT-PCR). **p<0.01, ***p<0.001 versus scramble siRNA group. C: pcDNA-GPX3-AS and scramble siRNA or GPX3 siRNA were cotransfected into SRA01/04 cells. GPX3 mRNA levels were detected by qRT-PCR. ***p<0.001 versus pcDNA GPX3-AS plus scramble group. D, E: SRA01/04 cells were transfected with pcDNA plus scramble siRNA, pcDNA plus GPX3 siRNA1, pcDNA-GPX3-AS plus scramble siRNA or pcDNA-GPX3-AS plus GPX3 siRNA1 for 24 h, respectively. Then, they were exposed to H₂O₂ for 24 h. Apoptotic cells were detected by flow cytometry. *p<0.05 versus pcDNA plus scramble siRNA group; ***p<0.001 versus pcDNA-GPX3-AS plus scramble siRNA group. n = 5 per group.