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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Mol Neurobiol. 2019 Jul 6;56(12):8589–8602. doi: 10.1007/s12035-019-01691-w

Figure 1: EAE induction and evaluation of clinical scores.

Figure 1:

A) Schematic representation of the time points of EAE induction and experiments performed. B) Animals were evaluated every day and the clinical scores were recorded according to a 0–5 scale (see methods section for details). WT EAE mice showed progressively increasing clinical score starting at day 9. A2−/− EAE mice showed significantly lower clinical score as compared to WT EAE mice. Both control groups showed no signs of motor deficits. *p<0.05, A2−/− EAE vs WT EAE for days 11-21, 24-37, 41-43 and 47. #p<0.05, WT and A2−/− EAE groups vs respective control groups starting at days 11 and 14 respectively, and till the end of the experiment. N = 17-26 per group. Four animals in WT EAE and two in A2 −/− EAE group died or were sacrificed due to weight loss. Data are presented as mean ± SEM.