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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Mol Immunol. 2019 Aug 6;114:260–268. doi: 10.1016/j.molimm.2019.07.029

Figure 2. Adoptive transferred EAE model.

Figure 2.

(a) CD4+ T cells isolated from wild-type 2D2 (WT) and Cd4-cre;Smad4fl/fl 2D2 (SMAD4 KO) mice were cultured with IL-21 and TGF-β receptor I inhibitor, and transferred into irradiated wild-type recipient mice on day0. Pertussis toxin was i.p. injected on day 0 and day 2. The EAE onset is day15. After 31 days, clinical scores (Mean ± SEM, n=10), (b) pathological and (c) flow cytometry and statistical analysis of EAE are shown. Lesions were indicated by the arrows in the figure.