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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Mol Immunol. 2019 Aug 6;114:260–268. doi: 10.1016/j.molimm.2019.07.029

Figure 6. Activin cooperates with IL-21 to promote Th17 differentiation through SKI.

Figure 6.

(a) CD4+ T cells isolated from wild-type (WT) mice were cultured with IL-21 and activin. After 4 days, IL-17A+ cells were analyzed by flow cytometry. Representative results and statistical analysis are shown. (b) CD4+ T cells isolated from wild-type (WT) or (c) Cd4-cre;Smad4fl/fl (SMAD4 KO) mice were cultured with IL-21 and activin, and then transduced with control retrovirus (RV) or SKI-expressing retrovirus (RV SKI). IL-17A+ cells were analyzed by flow cytometry. Representative results and statistical analysis are shown.