Table 3.

HCQ discontinuation and first flare manifestations

Patient characteristics	Did not discontinue HCQ n = 172 (33.8%)	Discontinued HCQ n = 337 (66.2%)	P value
Flares, n (%)
Any flare	70 (40.7)	114 (33.9)	0.13
Flare while taking HCQ	70 (40.7)	94 (27.9)	0.004
Flare after discontinuation		27 (8.0)	…
First flare symptoms, n (%)
Arthritis	32 (18.6)	41 (12.2)	0.050
Malar rash	7 (4.1)	15 (4.5)	0.84
Bullous lupus	0 (0.0)	1 (0.3)	0.99
Subacute cutaneous lupus	2 (1.2)	6 (1.8)	0.72
Lupus panniculitis	1 (0.6)	2 (0.6)	0.99
Photosensitivity	3 (1.7)	4 (1.2)	0.69
Discoid rash	4 (2.3)	13 (3.9)	0.44
Oral ulcers	6 (3.5)	6 (1.8)	0.23
Alopecia	9 (5.2)	17 (5.0)	0.93
Pleuritis	6 (3.5)	20 (5.9)	0.24
Pericarditis	0 (0.0)	1 (0.3)	0.99
Lupus nephritis	7 (4.1)	8 (2.4)	0.28
Seizure	2 (1.2)	4 (1.2)	0.99
Psychosis	0 (0.0)	3 (0.9)	0.55
Mononeuritis multiplex	0 (0.0)	2 (0.6)	0.55
Peripheral or cranial neuropathy	1 (0.6)	3 (0.9)	0.99
Vasculitis	2 (1.2)	4 (1.2)	0.99
Hemolytic anemia	1 (0.6)	5 (1.5)	0.67
Leukopenia	6 (3.5)	1 (0.3)	0.007
Lymphopenia	2 (1.2)	0 (0.0)	0.11
Thrombocytopenia	6 (3.5)	4 (1.2)	0.095
Hospitalization	14 (8.1)	17 (5.0)	0.17

Abbreviation: HCQ, hydroxychloroquine.