Table 4.

HCQ discontinuation and any flare manifestations

Patient characteristics	Did not discontinue HCQ n = 172 (33.8%)	Discontinued HCQ n = 337 (66.2%)	P value
Any flare symptoms, n (%)
Arthritis	38 (22.1)	56 (16.6)	0.13
Malar rash	12 (7.0)	26 (7.7)	0.76
Bullous lupus	0 (0.0)	1 (0.3)	0.99
Subacute cutaneous lupus	7 (4.1)	9 (2.7)	0.39
Lupus panniculitis	2 (1.2)	2 (0.6)	0.61
Photosensitivity	4 (2.3)	9 (2.7)	0.99
Discoid rash	6 (3.5)	18 (5.3)	0.35
Oral ulcers	12 (7.0)	11 (3.3)	0.057
Alopecia	15 (8.7)	22 (6.5)	0.37
Pleuritis	10 (5.8)	25 (7.4)	0.50
Pericarditis	3 (1.7)	2 (0.6)	0.34
Lupus nephritis	11 (6.4)	11 (3.3)	0.11
Seizure	3 (1.7)	5 (1.5)	0.99
Psychosis	0 (0.0)	5 (1.5)	0.17
Mononeuritis multiplex	0 (0.0)	3 (0.9)	0.55
Peripheral or cranial neuropathy	2 (1.2)	3 (0.9)	0.99
Vasculitis	4 (2.3)	6 (1.8)	0.74
Hemolytic anemia	3 (1.7)	5 (1.5)	0.99
Leukopenia	10 (5.8)	2 (0.6)	<0.001
Lymphopenia	3 (1.7)	1 (0.3)	0.11
Thrombocytopenia	9 (5.2)	6 (1.8)	0.029
Hospitalization	20 (11.6)	23 (6.8)	0.065

Abbreviation: HCQ, hydroxychloroquine.