Skip to main content
. 2019 Jun 6;1(4):267–276. doi: 10.1002/acr2.1039

Figure 2.

Figure 2

A, Impact of the NLRP3 c.1322C>T transition at the protein level. Exonic organization of the human NLRP3 cDNA and domain‐organization model of the corresponding protein. The identified mutation is indicated. The red asterisk shows the location of the identified mutation in the NACHT domain (top). PYD, pyrin domain; NACHT (NAIP,CIITA,HET‐E and TP1) domain; NAD, NACHT‐associated domain; LRR, leucine‐rich repeat domain. B, Partial interspecies alignment of NLRP3 showing the evolutionary conservation of the domain containing A441 (left panel), as well as the conservation of A441 in NLRP12, one of the human NLRP3 paralogs (right panel).