Table 1.
Baseline demographics, pulmonary and systemic hemodynamics, and pulmonary function of a systemic sclerosis–related pulmonary fibrosis cohort divided into subgroups either with pulmonary hypertension or without pulmonary hypertension
| Total (n = 31) | With PH (n = 22) | No PH (n = 9) | P Value | |
|---|---|---|---|---|
| Tissue Type | 0.029 | |||
| Autopsy | 9 (30.0%) | 9 (40.9%) | 0 | |
| Transplant | 22 (70.0%) | 13 (59.1%) | 9 (100%) | |
| Age at tissue acquisition (y) | 0.071 | |||
| Mean (SD) | 53.6 (11.5) | 56.0 (10.3) | 47.8 (12.6) | |
| Median (Q1‐Q3) | 55.0 (48.5‐60.0) | 55.0 (49.0‐63.8) | 50.0 (33.0‐58.0) | |
| Gender | 0.042 | |||
| Female | 19 (61.3%) | 12 (54.5%) | 7 (77.8%) | |
| Male | 12 (38.7%) | 10 (45.5%) | 2 (22.2%) | |
| Time from right heart catheterization to tissue acquisition (d) | 0.056 | |||
| Mean (SD) | 379.7 (428.1) | 286.5 (391.0) | 607.6 (451.1) | |
| Median (Q1‐Q3) | 168.0 (39.0‐718.5) | 152.0 (33.5‐232.0) | 771.0 (90.0‐956.0) | |
| Body mass index (kg/m 2 ) | 0.886 | |||
| Mean (SD) | 23.3 (3.7) | 23.2 (4.0) | 23.4 (3.1) | |
| Median (Q1‐Q3) | 23.0 (21.0‐25.5) | 23.0 (21.0‐24.8) | 22.0 (21.026.0) | |
| Systemic mean arterial pressure (mmHg) | 0.612 | |||
| Mean (SD) | 86.4 (13.1) | 87.1 (13.2) | 84.4 (13.6) | |
| Median (Q1‐Q3) | 84.0 (76.5‐93.0) | 85.0 (76.2‐97.5) | 79.0 (77.0‐90.0) | |
| Heart rate (beats/min) | 0.237 | |||
| Mean (SD) | 88.4 (14.4) | 86.4 (14.7) | 93.2 (13.2) | |
| Median (Q1‐Q3) | 88.0 (77.0‐96.0) | 82.5 (77.0‐94.5) | 91.0 (88.0‐102.0) | |
| Right atrial pressure (mmHg) | 0.007 | |||
| Mean (SD) | 9.9 (6.6) | 11.9 (6.8) | 5.1 (2.2) | |
| Median (Q1‐Q3) | 8.0 (5.5‐12.5) | 11.5 (7.2‐14.5) | 5.0 (5.0‐7.0) | |
| Mean pulmonary artery pressure (mmHg) | <0.001 | |||
| Mean (SD) | 39.1 (15.6) | 47.9 (8.1) | 17.7 (3.0) | |
| Median (Q1‐Q3) | 43.3 (22.5‐51.0) | 47.5 (42.6‐53.2) | 17.3 (15.7‐17.7) | |
| Pulmonary artery wedge pressure (mmHg) | 0.125 | |||
| Mean (SD) | 10.1 (4.0) | 10.8 (3.8) | 8.3 (4.3) | |
| Median (Q1‐Q3) | 10.0 (7.0‐13.5) | 10.5 (7.2‐13.8) | 6.0 (5.0‐11.0) | |
| Cardiac index (L/min/m 2 ) | 0.003 | |||
| Mean (SD) | 2.6 (0.8) | 2.4 (0.8) | 3.3 (0.6) | |
| Median (Q1‐Q3) | 2.4 (2.1‐3.0) | 2.2 (1.8‐2.5) | 3.2 (3.0‐3.7) | |
| Pulmonary vascular resistance (Wood units) | <0.001 | |||
| Mean (SD) | 7.4 (5.0) | 9.8 (3.9) | 1.7 (0.6) | |
| Median (Q1‐Q3) | 7.8 (2.3‐11.6) | 9.1 (7.1‐12.7) | 1.7 (1.5‐1.9) | |
| Forced vital capacity (L) | 0.019 | |||
| Mean (SD) | 1.7 (0.6) | 1.9 (0.6) | 1.3 (0.4) | |
| Median (Q1‐Q3) | 1.5 (1.3‐2.0) | 1.8 (1.4‐2.1) | 1.2 (1.2‐1.3) | |
| Missing | 1 | 1 | 0 | |
| Forced vital capacity (% predicted) | 0.04 | |||
| Mean (SD) | 45.5 (15.9) | 49.3 (15.9) | 36.4 (12.5) | |
| Median (Q1‐Q3) | 41.5 (34.5‐51.0) | 43.0 (38.0‐55.0) | 34.0 (28.0‐40.0) | |
| Missing | 1 | 1 | 0 | |
| Forced expiratory volume, 1 s (L) | 0.004 | |||
| Mean (SD) | 1.4 (0.6) | 1.6 (0.6) | 0.9 (0.2) | |
| Median (Q1‐Q3) | 1.2 (1.0‐1.6) | 1.5 (1.2‐1.8) | 1.0 (0.9‐1.1) | |
| Missing | 1 | 1 | 0 | |
| Forced expiratory volume, 1 s (% predicted) | 0.003 | |||
| Mean (SD) | 46.8 (18.4) | 53.0 (18.1) | 32.3 (8.9) | |
| Median (Q1‐Q3) | 45.5 (32.5‐54.5) | 50.0 (41.0‐56.0) | 32.0(26.0‐36.0) | |
| Missing | 1 | 1 | 0 | |
| Diffusing capacity (ml/min per mmHg) | 0.518 | |||
| Mean (SD) | 6.5 (4.1) | 6.9 (4.7) | 5.7 (2.3) | |
| Median (Q1‐Q3) | 5.7 (4.7‐7.4) | 5.8 (4.9‐6.9) | 4.8 (4.0‐7.6) | |
| Missing | 3 | 2 | 1 | |
| Diffusing capacity (% predicted) | 0.337 | |||
| Mean (SD) | 24.9 (10.4) | 23.7 (7.9) | 27.8 (15.0) | |
| Median (Q1‐Q3) | 21.0 (20.0‐30.8) | 21.0 (20.0‐28.0) | 21.0 (17.0‐36.0) | |
| Missing | 1 | 1 | 0 | |
| Supplemental oxygen at tissue acquisition (L/min) | 0.53 | |||
| Mean (SD) | 4.6 (3.2) | 4.8 (3.2) | 4.0 (3.3) | |
| Median (Q1‐Q3) | 4.0 (2.0‐6.0) | 4.0 (3.2‐6.0) | 2.0 (2.0‐5.0) | |