Table 2.

Secondary outcomes and methods assessments

Outcome category	Factors evaluated	Data source	Time points
Feasibility of telehealth approach	Technical feasibility of telehealth network for remote dermatological review of 3D TBP–SDDI images, and interoperability with hospital image repositories and integrated electronic medical records	Investigate subsystems for image acquisition, storage and display by measuring network throughput (bandwidth) and latency between subsystems. Measure data volume and transmission time per 3D TBP–SDDI examination. Assess the compression ratio of transmitted image files necessary to achieve adequate functionality. Evaluate success of transmission and integrity of data.	24 months
Accuracy of telehealth skin examinations	Safety and accuracy of teledermatology review of 3D TBP–SDDI images	Review the concordance between provisional diagnosis and clinical management decisions of the teledermatologist to the gold standard of in-person dermatological assessment. Assess comparative diagnostic accuracy between in-person clinical diagnosis, teledermatological diagnosis and histopathological diagnoses.	0–24 months
Melanoma-risk stratification in a high-risk population	Genetic results	Saliva samples collected using Oragene DNA self-collection kit. Methods for sample processing described previously.27	Baseline
		Whole exome sequencing or Sanger sequencing used to identify rare, pathogenic, germline variants in known melanoma genes. Common variants associated with melanoma risk will be genotyped using Illumina CoreExomev24 chip array.	12–24 months
	Sun behaviour	Self-administered, previously validated sun behaviour questionnaire to record sun protective behaviour, sun exposure, sunburn history, personal and family skin cancer history, and relevant demographic information.27 30	Baseline
	Deep phenotyping	Documentation of eye, hair and skin colour. Spectrophotometer readings for skin colour on the right arm including the proximal anterior bicep, proximal anterior forearm and proximal posterior forearm, using Spectrometer CM-600d (Konica Minolta, Osaka, Japan). Digital photographs of participant’s irises using a Nikon D3400 digital single-lens reflex camera (Nikon, Tokyo, Japan). Freckling on the face, dorsum of right hand and shoulders are rated 0–4 (none, mild, moderate, severe) to produce an overall freckling score.	Baseline

3D, three dimensional; SDDI, sequential digital dermoscopy imaging; TBP, total-body photography.