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. 2019 Nov 3;9(11):e030438. doi: 10.1136/bmjopen-2019-030438

Figure 3.

Figure 3

Kaplan-Meier curves for renal outcomes by occurrence of APN and/or AKI. (A, B) Patients with APN were significantly more likely to have a GFR reduction >30% (p<0.001) (A) and a GFR reduction >50% (p<0.001) (B). (C, D) In patients with severe AKI of grade II or III, the probability of GFR reduction >30% (p for pooled analysis <0.001, HR 1.58, 95% CI 1.37 to 1.82, pairwise analysis; p<0.001 for no AKI vs AKI stage II or III, and AKI stage I vs stage II or III) (C) and >50% (p for pooled analysis <0.001, HR 2.62, 95% CI 2.05 to 3.34, pairwise analysis; p<0.001 for no AKI vs AKI stage II or III, p=0.035 for AKI stage I vs II, p<0.001 for AKI stage I vs III, and p=0.001 for AKI stage II vs III) (D) was significantly higher than the others. (E, F) The prognosis was best when neither AKI nor APN was present, and the prognosis was progressively worse with AKI alone, APN alone, and both AKI and APN, consecutively (p for pooled analysis <0.001, HR 1.50, 95% CI 1.33 to 1.71, pairwise analysis: p=0.029 for AKI(−)APN(−) vs AKI(+), p=0.027 for AKI(−)APN(−) vs APN(+), p<0.001 for AKI(−)APN(−) vs AKI(+)APN(+), and p<0.001 for AKI(+) vs AKI(+)APN(+) (E); p<0.001 for pooled analysis, HR 2.18, 95% CI 1.75 to 2.71, pairwise analysis: p=0.024 for AKI(−)APN(−) vs AKI(+), p<0.001 for AKI(−)APN(−) vs AKI(+)APN(+), and p<0.001 AKI(+) vs AKI(+)APN(+) (F)). APN, acute pyelonephritis; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate.