Table 1.
Summary of measurements collected for the adjunct studies conducted in JECS-A
| Main items | Sub-cohort covered | Timing of measurement | |||||||||||
| A1 | A2 | A3 | B | C | Prenatal (trimester) | Postnatal (months after birth) | |||||||
| First | Second/third | 1 | 6 | 18 | 24 | 36 | |||||||
| Pregnant women | |||||||||||||
| Risk and confounding factors | |||||||||||||
| Sociodemographic | Age, maternal age, marital status, household income, education level | ○ | ○ | ○ | ○ | ○ | ○ | ||||||
| Lifestyle | Smoking, secondhand smoking, drinking habits, dietary status, sleeping habits | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | |
| Psychological and psychiatric | TAS-20 | ● | ● | ● | |||||||||
| POMS-SF | ● | ● | |||||||||||
| Readiness of Parenthood Scale | ● | ● | ● | ● | ● | ||||||||
| Obstetric | History of pregnancy, infertility treatment, prenatal diagnosis and gestational duration | ○ | |||||||||||
| Biomonitoring data | Urine (up to 50 mL, mothers only), parental blood (up to 1.5 mL), cord blood (up to 1.5 mL) | ● | ● | ● | ● | ● | |||||||
| Children | |||||||||||||
| Risk and confounding factors | |||||||||||||
| Demographic | Height, weight, BMI, sex | ○ | ○ | ○ | ○ | ○ | |||||||
| Behavioural | Neonatal oral–motor assessment | ● | ● | ||||||||||
| DCDQ | ● | ● | ● | ||||||||||
| Childcare | Breast feeding and weaning food status | ● | ● | ||||||||||
| Psychological and psychiatric | Mary Rothbart's Temperament Questionnaires | ● | |||||||||||
| IBQ-R-SF | ● | ||||||||||||
| ECBQ-SF | ● | ||||||||||||
| Biomonitoring data | Overnight urine extracted from disposable diapers (up to 30 mL) | ● | ● | ● | |||||||||
| Anthropometric data | 2D:4D | ● | ● | ● | |||||||||
| Outcome examples to be analysed | |||||||||||||
| LBW | ○ | ○ | ○ | ||||||||||
| ASD | ○ | ○ | ○ | ○ | ○ | ○ | |||||||
| ADHD | ○ | ○ | ○ | ○ | ○ | ||||||||
Sub - cohort A1, agreement on the adjunct questionnaire survey only; s ub - cohort A2, agreement on the adjunct questionnaire survey and provision of mother’s biological specimen (blood and urine); s ub - cohort A3, agreement on the adjunct questionnaire survey and provision of mother’s biological specimen (blood and urine) with genetic analyses; s ub - cohort B, informed consent obtained from guardians (legally acceptable representatives) for anthropometry measurement on child hands; s ub - cohort C, informed consent obtained from guardians (legally acceptable representatives) for provision of child’s biological specimen.
○: Refer to the main study of the JECS.
●: Measurements conducted solely in the JECS-A.
ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder;BMI, body mass index; DCDQ, Developmental Coordination Disorder Questionnaire; 2D:4D, the second to fourth digit ratio; ECBQ-SF, Early Childhood Behavior Questionnaire Short Form; IBQ-R-SF, The Infant Behavior Questionnaire Revised Short Form;JECS, Japan Environment and Children’s Study; JECS-A, The Aichi regional sub-cohort of the Japan Environment and Children’s Study; LBW, low birth weight; POMS-SF, Short form of the Profile of Mood States; TAS-20, the 20-item Toronto Alexithymia Scale.