Table 2.
Physicochemical properties of the native and mutants (R74C, S66W, and R245H) in the SGSH protein
| Physicochemical Properties | R74C | S66W | R245H | |||
|---|---|---|---|---|---|---|
| Native (Arginine) | Mutant (Cysteine) | Native (Serine) | Mutant (Tryptophan) | Native (Arginine) | Mutant (Histidine) | |
| Side-chain flexibility | High | Low | Low | Moderate | High | Moderate |
| Interaction mode | Ionic, H-bonds, van der Waals | Covalent disulfide bonds, van der Waals | H-bonds, van der Waals | H-bond, aromatic stacking, van der Waals | Ionic, H-bonds, van der Waals | Ionic, H-bonds, aromatic stacking, van der Waals |
| Potential side chain H-bonds | 7 | 0 | 3 | 1 | 7 | 3 |
| Residue Molecular Weight | 156 | 103 | 87 | 186 | 156 | 137 |
| Hydrophobicity | 0.000 | 0.721 | 0.601 | 0.854 | 0.000 | 0.548 |
| Polarity | Polar | Non-polar | Polar | Non-polar | Polar | Polar |
| General Property | Aliphatic | Aliphatic | Aliphatic | Aromatic | Aliphatic | Aromatic |