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. 2019 Nov 15;2:415. doi: 10.1038/s42003-019-0664-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic of the study protocol and data from an illustrative subject. a We acquired data using a randomized, cross-over study design. Anesthetic-drugs were administered for approximately 45 min. b, c End-tidal sevoflurane concentration, behavioral response probability curve, and corresponding frontal electroencephalogram spectrogram during the sevoflurane study visit. d, e End-tidal sevoflurane concentration, behavioral response probability curve, and corresponding frontal electroencephalogram spectrogram during the sevoflurane-plus-ketamine study visit. Shaded regions represent the 95% confidence bounds. Sevo sevoflurane, Ket Ketamine