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. 2019 Nov 15;2:418. doi: 10.1038/s42003-019-0651-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Electron micrographs showing axon terminals containing α-syn peroxidase immunolabeling (green labels) making excitatory (blue arrows) and inhibitory (red arrows) contacts onto VTA dendrites. b Quantification of characterized synaptic contacts onto TH+ and TH− dendrites in the VTA showing that when systemically present, repeated cocaine (rep coc+) increased α-syn immunolabeling in axon terminals making excitatory-type synaptic contacts onto dopamine dendrites (teal arrow). When cocaine or its metabolites were no longer systemically present (rep coc−), α-syn immunolabeling was increased in axon terminals making inhibitory-type synaptic contacts onto non-dopaminergic dendrites in the VTA (yellow arrow). c Electron micrographs showing the selectivity of α-syn immunolabeling. Axon terminals with (teal arrows) and without (blue arrows) α-syn immunolabeling can be seen making excitatory-type synaptic contacts onto the same dopamine (TH+) or non-dopamine dendrite within the VTA. Similarly, axon terminals with (yellow arrow) or without (red arrow) α-syn labeling can be seen making inhibitory contacts onto the same dopamine dendrite. Scale bar = 500 nm; den = dendrite; ter = axon terminal; UL = unlabeled