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. 2019 Nov 15;9:16928. doi: 10.1038/s41598-019-53294-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment effects on behavior in an open field. Data are expressed as Mean + SEM (Male n = VV: 13, PV: 18, VL: 11, PL: 17) (Female n = VV: 17, PV:17, VL: 10, PL: 10). Postnatal LPS significantly reduced center time in males, and effect that was greatest in the PL (“two-hit”) condition, without producing significant effects in females (A). Locomotor activity was not significantly altered in males, but was significantly decreased in females following LPS, especially when combined with Poly I:C. (B). *P < 0.05, **P < 0.01 compared to VV, Bonferroni’s tests.