Figure 1.
Anti-PD1-induced delay in tumor growth is enhanced in small tumors, independently of treatment schedule. (A) Experimental design. DBA/2 mice bearing allogenic KLN-205 squamous lung cancer tumor allografts originated from injection of 104 to 107 cells were treated with intra-peritoneal anti-PD1 (100 µg per week or 200 µg twice a week from day 14 after allograft). Tumor size was measured twice a week with caliper. Control mice were treated with isotype control. Six animals were used in each group (i.e. mice receiving the same number of cells and the same treatment). Error bars represent the standard error for mean. (B) Absolute tumor volume during treatment with anti-PD1. (C) Tumor volume relatively to the volume at treatment initiation. (D) Legend for (B,C) graphes.