Table 1.
Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of θ-defensin RTD-1 and clinical antifungalsa.
| RPMI | 50% serum | |||||||
|---|---|---|---|---|---|---|---|---|
| C. albicans # | RTD-1 | Fluco | Caspo | RTD-1 | ||||
| MIC | MFC | MIC | MFC | MIC | MFC | MIC | MFC | |
| SC5314 | 12.5 | 25 | 64 | >256 | 0.06 | 0.25 | >100 | >100 |
| 43001 | 6.25 | 12.5 | >256 | >256 | 2 | 2 | >100 | >100 |
| 53264 | 12.5 | 12.5 | >256 | >256 | >8 | >8 | >100 | >100 |
aA modified CLSI protocol, described in Methods, was used to determine MICs for RTD-1, fluconazole (Fluco) and caspofungin (Caspo). MFC assays were conducted as described in Material and Methods. MFC values correspond to 99% killing relative to input inoculum. MICs and MFCs for RTD-1 were determined also in 50% serum as described in Material and Methods.