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. 2019 Nov 15;9:16937. doi: 10.1038/s41598-019-53276-1

Figure 1.

Figure 1

Aspirin overcomes the resistance to 5-Fu and enhances the sensitivity to 5-Fu in CRC cells. (A) The established 5-Fu resistant CRC cell lines SW620-FU and SW480-FU were treated with indicated concentrations of aspirin (ASA) or 5-Fu (FU), respectively, and the cell viability was measured at 72 h through MTT assay. (B) SW480 and SW620 were treated by 2.5 mM ASA, 20 μM FU, or both of the two drugs (A + F), respectively, and the cell viability was measured at 48 h and 72 h, separately, by MTT assay. (C) SW480-FU and SW620-FU were treated by 2.5 mM ASA, 150 μM FU, or both of the two drugs (A + F), respectively, and the cell viability was measured at 48 h and 72 h, separately, by MTT assay. (D) CRC cells were treated as described above, and apoptosis was measured at 72 h later by FACS analysis. The data are presented as means ± SD (**P < 0.01, *P < 0.05).