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. 2019 Jul 11;40(6):1605–1625. doi: 10.1210/er.2018-00262

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Copyright © 2019 Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 1. — Schematic overview of steroidogenesis and corresponding urine steroid metabolites. Steroids are color-coded according to their bioactivity or commitment to a specific pathway: general precursors (yellow), mineralocorticoid precursors (light green), active mineralocorticoid (dark green), glucocorticoid precursors and inactive metabolite (light orange), active glucocorticoid (dark orange), androgen precursors (light blue), and active androgens (dark blue). Corresponding urinary metabolites are shown in yellow boxes. Arrows are labeled with the catalyzing enzyme and isoform. Essential cofactor proteins are also indicated: ADX, adrenodoxin; b₅, cytochrome b₅; PAPSS2, PAPS synthase 2; PRO, cytochrome P450 oxidoreductase; StAR, steroidogenic acute regulatory protein.