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Post-translational regulation of caspase-3 and PC-3 activity via inhibitory zinc. (A) Graphical representation of inhibitory zinc on caspase-3.121 Protein structure displayed is PDB: 2XYG. (B) Zinc binding inhibits PC-3 autocatalysis to form caspase-3. Upon zinc liberation, PC-3 can autoactivate to form caspase-3. Adapted with permission from ref 28. Copyright 2009 Elsevier.
