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. 2019 Oct 22;11(45):41906–41924. doi: 10.1021/acsami.9b14670

Table 2. ECM Genes Expressed during Chondroprogenitor Cell Differentiation on GF.

  functional classification: ECM
  
  gene symbol protein name function in chondrogenesis reference
1 Col1a1 Collagen α1(I) major fibrillar collagen Treilleux 199275
2 Col2a1 Collagen α1(II) major fibrillar collagen Liu 201376 Atsumi 199035
3 Col3a1 Collagen α1(III) fibrillar collagen Lodewyckx 201277
4 Col5a1 Collagen α1(V) fibrillar collagen Lodewyckx 201277
5 Col6a1 Collagen α1(VI) pericellular collagen Zelenski 201578
6 Ecm1 Extracellular matrix protein-1 interacts with perlecan; regulates chondrogenesis Kong 201679 Mongiat 200380
7 Emilin1 Elastin microfibril interface-located protein 1 integrin binding activity; tissue remodeling in noncartilaginous tissues This paper for chondrocyte differentiation*
8 Fn1 Fibronectin essential for early chondrocyte differentiation White 200381 Singh 20148
9 Hapln1 Hyaluronan and proteoglycan link protein 1 organizes extracellular matrix; links proteoglycan to hyaluronan Xu 200882
10 Lamb3 Laminin subunit beta-3 basement membrane protein; promotes chondrogenesis Sun 201783
11 Postn Periostin basement membrane protein; promotes chondrogenesis Inaki 201884
12 Sparc Secreted protein acidic and rich in cysteine; Osteonectin matricellular protein with calcium-binding properties; osteonectin, functions in growth and remodeling Sage 198985
13 Spp1 Secreted phosphoprotein; Osteopontin Bone sialoprotein 1 small integrin-binding ligand, N-linked glycoprotein Shibata 200286
14 Thbs1 Thrombospondin 1 matricellular protein; modulates cell–matrix interactions; Cartilage protection; Miller 198887 DiCesare 199488 Pfander 200089 Maumus 201790
15 Thbs2 Thrombospondin 2 matricellular protein; interacts with cell surface; regulates the bioavailability of proteases and growth factors in the pericellular environment Jeong 201591
16 Tnc Tenascin hexameric extracellular matrix glycoprotein prevalent in development; modulates cellular adhesion and interaction with fibronectin among other proteins Gluhak 199692 Unno 201993 Mackie 198794