. Author manuscript; available in PMC: 2020 Apr 14.

Published in final edited form as: Nat Struct Mol Biol. 2019 Oct 14;26(11):999–1012. doi: 10.1038/s41594-019-0313-z

Table 1.

A list of the validated essential PRMT5 substrates.

Substrate name	Description
ALYREF	Aly/REF Export Factor
SUPT5H	Transcription elongation factor
CPSF6	Cleavage and Polyadenylation Specific Factor 6
SNRPB	Small Nuclear Ribonucleoprotein Polypeptides B and B1
SFPQ	Splicing Factor Proline and Glutamine Rich
PNN	Pinin
SRSF1	Serine and Arginine Rich Splicing Factor 1
WDR33	pre-mRNA 3’end processing protein
RPS10	Ribosomal Protein S10
CCT4	T-complex protein 1 subunit delta
CCT7	T-complex protein 1 subunit eta

*in green – published PRMT5 substrates