Table 3.
miRNAs in Fib activation and tissue fibrosis
| miRNA | Organ | Expression | Effect on fibrosis | References |
|---|---|---|---|---|
| miR-21 | Lung, liver, heart, and kidney | ↑ | Pro-fibrotic | [192–195] |
| miR-31 | Skin | ↑ | Pro-fibrotic | [196] |
| miR-34a | Liver, kidney, and lung | ↑ | Pro-fibrotic | [197–199] |
| miR-96 | Lung | ↑ | Pro-fibrotic | [200] |
| miR-145 | Lung | ↑ | Pro-fibrotic | [201] |
| miR-154 | Lung | ↑ | Pro-fibrotic | [202] |
| miR-155 | Lung, skin, and heart | ↑ | Pro-fibrotic | [203–205] |
| miR-199a-5p | Lung | ↑ | Pro-fibrotic | [206] |
| miR-210 | Lung | ↑ | Pro-fibrotic | [207] |
| miR-9-5p | Lung | ↓ | Anti-fibrotic | [208] |
| miR-22 | Heart | ↓ | Anti-fibrotic | [209] |
| miR-26a | Lung | ↓ | Anti-fibrotic | [210] |
| miR-27a-3p | Lung | ↓ | Anti-fibrotic | [211] |
| miR-29a,b,c | Lung | ↓ | Anti-fibrotic | [212] |
| miR-101 | Lung | ↓ | Anti-fibrotic | [213] |
| miR-200b,c | Lung | ↓ | Anti-fibrotic | [214] |
| miR-150 & miR-194 | Liver | ↓ | Anti-fibrotic | [215] |