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. 2019 Nov 15;20:863. doi: 10.1186/s12864-019-6221-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Advanced bubble chart shows significantly enriched pathways based on differentially expressed genes (DEGs) by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (p < 0.05). The x-axis represents rich factor (rich factor = number of DEGs enriched in the pathway/number of all genes in the background gene set). The y-axis represents the enriched pathway. Color represents enrichment significance, and the size of the bubble represents the number of DEGs enriched in the pathway