Table 4.

Event rates and odds ratios^* for readmission and mortality within 365 days in patients with asthma following an acute hospitalization, stratified by blood eosinophil count (n = 1268)

Follow-up	Variable	Readmission			Mortality
Analysis	Eosinophils	Events (%)‡	OR (95% CI)	P-value	Events (%)‡	OR (95% CI)	P-value
30 days	Continuous		0.98 (0.9–1.1)	0.64		0.77 (0.5–1.1)	0.137
Adjusted	Low	87 (19.2%)	1		14 (3.1%)	1
	Medium	45 (19.0%)	0.99 (0.7–1.5)	0.94	1 (0.4%)	0.26 (0.03–2.1)	0.21
	High	47 (14.1%)	0.75 (0.5–1.1)	0.16	3 (0.9%)	0.73 (0.2–2.9)	0.65
	Total events§	179 (40.6%)			18 (33.3%)
90 days	Continuous		0.95 (0.9–1.0)	0.21		0.79 (0.6–1.0)	0.035
Adjusted	Low	129 (28.5%)	1		26 (5.8%)	1
	Medium	75 (31.6%)	1.15 (0.8–1.6)	0.43	5 (2.1%)	0.48 (0.2–1.5)	0.21
	High	68 (20.4%)	0.66 (0.5–0.9)	0.019	4 (1.2%)	0.41 (0.1–1.3)	0.12
	Total events§	272 (61.7%)			35 (64.8%)
365 days†	Continuous		0.94 (0.9–1.0)	0.11		0.70 (0.6–0.9)	0.001
Adjusted	Low	207 (45.8%)	1		41 (9.1%)	1
	Medium	113 (47.7%)	0.99 (0.7–1.4)	0.94	8 (3.4%)	0.42 (0.2–1.0)	0.061
	High	121 (36.2%)	0.64 (0.5–0.9)	0.0051	5 (1.5%)	0.25 (0.09–0.7)	0.008
	Total events§	441 (100%)			54 (100%)

^*Multivariable adjusted analyses included age, sex, Charlson comorbidity score, suPAR and CRP

^‡Shown as number of patients with event (percentage out of total patient population in each group of blood eosinophil count (low, medium, high) at 365 days)

^†Only patients with a minimum of 365 days follow-up included in analyses (n = 1068)

Cut-offs defined as Low (< 150 cells/μL, n = 452), Medium (150–300 cells/μL, n = 237), and High (> 300 cells/μL, n = 334)

^§Total number of events at follow-up as a percentage of number of events at 365 days

CRP – C-Reactive Protein

CI – Confidence Interval

OR – Odds Ratio

suPAR – Soluble Urokinase Plasminogen Activator Receptor