Table 4.
AG490 treatment reduces neurologic deficits in GET-1 and Ntg mice at 7 days after tMCAO
| Group | Neurological scores | Average scores | |||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | ||
| Ntg + vehicle(n = 15) | 9 | 6 | 0 | 0 | 0.4 |
| Ntg + AG490 (n = 8) | 7 | 1 | 0 | 0 | 0.125 |
| GET-1 + vehicle (n = 17) | 1 | 9 | 7 | 0 | 1.35*** |
| GET-1 + AG490 (n = 9) | 4 | 3 | 2 | 0 | 0.78# |
Numbers of mice having various degrees of neurologic deficits after tMCAO. Numbers 0–3 in the top row represent severity of neurologic deficits with 0 being normal and 3 being the most severe
Ntg nontransgenic, MCAO middle cerebral artery occlusion
The asterisk denotes significant difference between the mean neurological scores of Ntg and GET-1 mice, p < 0.01