Fig. 5.

Dacinostat and quisinostat attenuate tumorigenesis of medulloblastoma xenografts in NSG mice. a, b Tumor volumes during treatment were measured using calipers. Values were presented as the mean ± SE. c, d Gross tumors at day 18 post-treatment. e, f Tumor weights at day 18 post-treatment. g, h Body weight during treatment was measured. Values were presented as the mean ± SE. i Histological analysis of tumor. Representative images of immunohistochemistry staining for Ki67 and cleaved PARP in tumor tissues were shown. Black arrows pointed to cells with positive staining. HE hematoxylin and eosin staining