Table 2.

Predictors of time to first hHF (SMQ definition)

Baseline predictor	Hazard ratio [95% CI]	Relative importance	P-value
Prior heart failure (Y vs. N)	4.89 [3.90; 6.14]	54.6	< 0.0001
Hepatic impairment (Y vs. N)	3.08 [2.15; 4.41]	11.0	< 0.0001
eGFR (log regression)	0.44 [0.34; 0.58]	10.0	< 0.0001
Atrial fibrillation (Y vs. N)	1.95 [1.50; 2.55]	7.2	< 0.0001
Total insulin dose (U/kg) at week 1	1.53 [1.27; 1.84]	5.9	< 0.0001
Prior myocardial infarction (Y vs. N)	1.54 [1.23; 1.91]	4.3	0.0001
Macular edema (Y vs. N)	3.77 [1.40; 10.2]	2.0	0.0087
A1C (squared regression)	1.00 [1.00; 1.01]	1.8	0.0137
Proteinuria (microalbuminuria and gross proteinuria)	1.36 [1.06; 1.73]	1.8	0.0140
Systolic blood pressure at baseline	1.01 [1.00; 1.01]	1.5	0.0251

Variables identified by stepwise selection − FAS. Relative importance is calculated as 100 × Chi square/Total Chi square, where the Chi squares are from a model simultaneously considering all effects mentioned in the table

A1C glycosylated hemoglobin, CI confidence interval, eGFR estimated glomerular filtration rate, FAS full analysis set, hHF hospitalization for heart failure, N no, SMQ standardized Medical Dictionary for Regulatory Activities Query, U units, Y yes