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. 2019 Nov 12;11:9571–9583. doi: 10.2147/CMAR.S219872

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© 2019 Mairinger et al.

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Forest-plot of the genes included in the DFS and OS scores. The figure illustrates the influence of tumors gene expression to patients recurrence-free (upper lines) or overall (lower lines) survival. Hazard ratios (squared dots) as well as the 95CI (black lines) are shown. High expression levels of IKBKG are associated with shortened RFS, whereas the remaining three (HSD11B1, DMBT1, CKLF) associate with prolonged RFS. For overall survival, only SDHA expression results in prolonged, whereas the others associate to shortened overall survival rates. For RFS, HSD11B1 and IKBKG seem to have the strongest impact on prolonged and shortened survival, respectively. For both, 95% CI does not overlap the HR of 1, giving a clear hint for the meaning of the presented association. For OS, LY96 and ATG5 seem to have the strongest impact on prolonged OS under platin-based chemotherapy. Interestingly, none of the markers made it to both scores. Of note, only IKBKG (RFS) and SDHA (OS) indicate a shortened survival time.