Table 2. Characteristics of miRNAs interaction in mRNA of BC subtype luminal A and B.
| Gene, RPKM | miRNA | Start of binding site, nt | ΔG, kJ/mole | ΔG/ΔGm, % | Length, nt |
|---|---|---|---|---|---|
| FOXA1 | ID00297.5p-miR | 99 | −123 | 89 | 24 |
| 10.2 | ID02106.3p-miR | 110 | −123 | 89 | 23 |
| ID00252.5p-miR | 111 | −140 | 94 | 24 | |
| ID02769.5p-miR | 112 | −127 | 92 | 22 | |
| ID01099.5p-miR | 116 | −108 | 100 | 17 | |
| ID01190.5p-miR | 118 | −108 | 100 | 17 | |
| ID00296.3p-miR | 115 | −140 | 89 | 25 | |
| ID01641.3p-miR | 122 | −134 | 90 | 24 | |
| ID01403.5p-miR | 120 | −123 | 91 | 23 | |
| ID00061.3p-miR | 127 | −129 | 94 | 22 | |
| ID03367.5p-miR (2) | 121 ÷ 122 | −117 | 93 | 20 | |
| miR-3960 | 120 | −115 | 92 | 20 | |
| ID00071.3p-miR (2) | 118 ÷ 121 | −117 ÷−121 | 93 ÷ 97 | 20 | |
| ID02457.3p-miR | 118 | −108 | 100 | 17 | |
| ID02595.5p-miR | 118 | −115 | 92 | 20 | |
| ID01702.3p-miR | 120 | −140 | 89 | 25 | |
| ID00457.3p-miR | 124 | −123 | 91 | 22 | |
| ID02499.3p-miR (2) | 127 ÷ 130 | −119 ÷−121 | 92 ÷ 93 | 21 | |
| HMGA2 | miR-6756-5p | 529 | −117 | 87 | 23 |
| 0.0 | ID01737.3p-miR | 539 | −119 | 93 | 21 |
| ID01041.5p-miR (2) | 541 ÷ 544 | −129 ÷−134 | 88 ÷ 91 | 24 | |
| ID00089.3p-miR | 542 | −125 | 91 | 22 | |
| ID01323.3p-miR | 542 | −117 | 95 | 20 | |
| ID02296.5p-miR | 542 | −115 | 93 | 20 | |
| ID0296.3p-miR | 544 | −146 | 93 | 25 | |
| ID01641.3p-miR | 544 | −142 | 96 | 24 | |
| ID01403.5p-miR | 547 | −119 | 88 | 23 | |
| ID00061.3p-miR | 550 | −132 | 95 | 22 | |
| ID03367.5p-miR | 550 | −115 | 92 | 20 | |
| miR-3960 | 549 | −117 | 93 | 20 | |
| miR-4739 | 573 | −123 | 87 | 25 | |
| ID00425.5p-miR | 575 | −121 | 88 | 24 | |
| ID00564.5p-miR | 585 | −110 | 90 | 22 | |
| ITGB1* | ID02187.5p-miR | 91 | −127 | 92 | 23 |
| 63.6 | miR-4787-5p | 92 | −123 | 92 | 22 |
| ID00457.3p-miR | 95 | −123 | 91 | 22 | |
| ID02770.5p-miR | 98 | −117 | 93 | 20 | |
| ID01184.3p-miR | 101 | −117 | 93 | 20 | |
| HMGA2** | ID01970.3p-miR | 1,255 | −113 | 90 | 23 |
| 0.0 | ID00849.3p-miR (2) | 1,261 ÷ 1,268 | −117 | 90 | 22 |
| ID01545.3p-miR | 1,275 | −115 | 95 | 21 | |
| SMAD3** | miR-4690-5p | 2,066 | −115 | 92 | 22 |
| ID02822.5p-miR | 2,070 | −127 | 91 | 23 | |
| ID00978.5p-miR | 2,072 | −119 | 90 | 22 | |
| miR-6089 (2) | 2,073 ÷ 2,078 | −132 ÷−136 | 89 ÷ 91 | 24 | |
| ID01382.3p-miR | 2,075 | −113 | 93 | 20 | |
| miR-3620-5p (2) | 2,069 ÷ 2,074 | −117 ÷−115 | 87 ÷ 89 | 22 | |
| SOX4** | ID01839.3p-miR | 2,994 | −123 | 89 | 23 |
| 13.2 | ID01282.3p-miR | 3,000 | −125 | 95 | 23 |
| ID03445.3p-miR | 3,000 | −127 | 90 | 24 | |
| ID00101.3p-miR | 3,001 | −115 | 92 | 22 | |
| TGFB1** | ID03306.3p-miR | 2,060 | −123 | 94 | 21 |
| 19.5 | miR-6089 (4) | 2,060 ÷ 2,095 | −132 ÷−136 | 89 ÷ 91 | 24 |
| ID01382.3p-miR | 2,062 | −113 | 93 | 20 | |
| miR-3620-5p | 2,086 | −115 | 87 | 22 | |
| ID03208.5p-miR | 2,066 | −125 | 88 | 24 | |
| ID00978.5p-miR | 2,089 | −119 | 90 | 22 | |
| ID00296.3p-miR | 2,093 | −140 | 89 | 25 |
Notes.
Genes without *—miRNA binding sites are in the 5′UTR, genes with *—miRNA binding sites are in the CDS, **—miRNA binding sites are in the 3′UTR; values in parentheses indicate the number of binding sites; ÷—the change of the parameter in the interval. Different repeating clusters of miRNA binding sites in different genes are coloured.