Table 2.
PK parameters of AZD7594 following single inhaled dose, geometric mean (CV%)
| Parameter (unit) | Summary statistics | 200 µg (N=7) | 400 µg (N=7) | 1600 µg (N=7) |
|---|---|---|---|---|
| Cmax (pmol/L) | Geometric mean | 56.05 | 76.93 | 430.8 |
| (CV%) | (22.0) | (34.4) | (22.4) | |
| AUC (h*pmol/L) | Geometric mean | NC | NC | 18260a |
| (CV%) | (NA) | (NA) | (22.9) | |
| AUC (0-last) (h*pmol/L) | Geometric mean | 1314 | 2736 | 13,960 |
| (CV%) | (28.2) | (12.2) | (18.2) | |
| tmax (h) | Median | 0.25 | 0.52 | 0.50 |
| (min; max) | (0.25; 0.98) | (0.25; 3.00) | (0.25; 4.00) | |
| t½λz (h) | Arithmetic mean | 39.88a | NC | 43.57b |
| (SD) | (5.44) | (NA) | (3.815) | |
| fe (0-last) (%) | Arithmetic mean | 0.002 | 0.002 | 0.016 |
| (SD) | (0.004) | (0.003) | (0.010) | |
| CLR (L/h) | Arithmetic mean | 0.003 | 0.005 | 0.029 |
| (SD) | (0.008) | (0.006) | (0.017) |
Notes: an=5; bn=4.
Abbreviations: CV%, geometric coefficient of variation; N, number in the pharmacokinetic analysis set; NA, not applicable; NC, not calculable; SD, standard deviation.