Table 3.
PK parameters of AZD7594 following inhaled dosing for 12 days, geometric mean (CV%)
| Parameter (unit) | Summary statistics | 200 µg (N=7) | 400 µg (N=7) | 1600 µg (N=7) |
|---|---|---|---|---|
| Css,max (pmol/L) | Geometric mean | 164.3 | 261.2 | 1206 |
| CV% | (14.0) | (37.0) | (14.7) | |
| Cav (pmol/L) | Geometric mean | 101.1 | 183.7 | 867.8 |
| CV% | (13.4) | (33.4) | (13.2) | |
| AUC (0–24) (h*pmol/L) | Geometric mean | 2426 | 4409 | 20,830 |
| CV% | (13.4) | (33.4) | (13.2) | |
| tss,max (h) | Median | 0.25 | 1.50 | 1.50 |
| (min; max) | (0.25; 4.02) | (0.25; 8.00) | (0.25; 4.00) | |
| RAC | Geometric mean | 3.562 | 4.067 | 3.437 |
| (SD) | (15.7) | (43.7) | (7.3) |
Abbreviations: CV%, geometric coefficient of variation; N, number of subjects in the pharmacokinetic analysis set; SD, standard deviation.