Extended Data Table 2. Features of individual FA core complex subunits and structural models.

Protein	Length (aa)	Sequence features	Models generated in this study	Maps used for modelling	Sequence identity / similarity between Gallus gallus and Homo sapiens (%)
FANCA	1,421	α-helical	N/A	N/A	49.1 / 65.6
FANCB	867	Possible (β-propeller, plus α-helical	De novo modelling of SSEs*	Focused map for top (EMD-10291), middle (EMD-10292), and base regions (EMD-10293), consensus map with T=5 (EMD-10290) and subcomplex map (EMD-10294)	44.1 / 63.2
FANCC	559	α-helical	SSEs placed in maps, not assigned	Focused map for base (EMD-10293)	49.0 / 65.1
FANCE	520	α-helical Crystal structure of human orthologue (C-terminal half; PDB 2ILR)	SSEs placed in maps, not assigned	Focused map for base (EMD-10293)	40.9 / 54.1
FANCF	350	α-helical Crystal structure of human orthologue (C-terminal half; PDB 2IQC)	C-terminal region from homology model based on PDB 2IQC	Focused map for base (EMD-10293)	38.5 / 51.6
FANCG	648	α-helical (TPR)	TPR domain from homology model (I- TASSER)	Focused map for top region (EMD-10291)	37.3 / 52.9
FANCL	373	ELF, URD and RING domains. Crystal structures of human (central domain, PDB 3ZQS; RING domain, PDB 4CCG) and Drosophila orthologues (full-length, PDB 3K1L)	ELF domain in FANCLtop. ELF, URD and RING domains in FANCLbase. Homology models based on PDB 3K1L	Focused map for top (EMD-10291) and base (EMD-10293)	69.9 / 82.7
FAAP100	888	Possible β-propeller, plus α-helical	De novo modelling of SSEs	Focused map for top (EMD-10291), middle (EMD-10292), and base regions (EMD-10293), consensus map with T=5 (EMD-10290) and subcomplex map (EMD-10294)	55.6 / 68.7

Footnote: * SSE, secondary structure elements