Table 1.
In vitro receptor binding profile of lurasidone compared with other atypical antipsychotics [14]
| Receptora | Antipsychotic | ||||
|---|---|---|---|---|---|
| Lurasidone | Olanzapine | Quetiapine | Risperidone | Aripiprazole | |
| D2 | +++ | ++ | + | +++ |
+++ PA |
| 5-HT1A |
+++ PA |
– |
+ PA |
+ |
+++ PA |
| 5-HT2A | +++ | +++ | ++ | ++++ | ++ |
| 5-HT1C | + | ++ | + | ++ | + |
| 5-HT7 | ++++ | + | ++ | +++ | +++ |
| α1 | ++ | ++ | +++ | +++ | ++ |
| α2a/2c | ++ | +/++ | + | ++/+++ | ++ |
| M1 | – | ++ | ++ | – | – |
| H1 | – | +++ | +++ | ++ | ++ |
Binding strengths are shown for receptor antagonism, unless indicated otherwise: +: weak; ++: moderately strong; +++: strong; ++++ : very strong; PA partial agonist
aD Dopamine receptor, 5-HT 5-hydroxytryptamine (serotonin) receptor, α alpha adrenergic receptor, M muscarinic acetylcholine receptor, H histamine receptor