| This paper shows new effects of fingolimod on the immune system beyond its sequestration ability. |
| Fingolimod is an effective drug in adults with relapsing–remitting MS and in pediatric forms of the disease. |
| Fingolimod negatively regulates Th1 and Th17 differentiation while promoting Th2 differentiation. |
| Fingolimod exerts its effects through action on B lymphocytes. |
| Fingolimod not only modulates lymphocyte trafficking but is able to modulate the composition of B- and T-cell subsets. |
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