Fig. 1.

Region of interest analysis. WM regions of interest with increased MD in asymptomatic and symptomatic MAPT mutation carriers compared with noncarriers are displayed on a rendered transparent brain from a single participant (colored in red). WM regions of interest with reduced FA in symptomatic MAPT mutation carriers compared with noncarriers are colored in green. MD and FA values from regions of interest that distinguished the MAPT mutation carriers from noncarriers with an area under the receiver operating characteristic curve (AUROC) of p < 0.05 after adjusting for age and correcting for multiple comparisons. Abbreviations: FA, fractional anisotropy; MAPT, microtubule-associated protein tau; MD, mean diffusivity; WM, white matter. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)