Table 1.
Participant characteristics at the baseline
| Noncarrier (N = 20) | Asymptomatic (N = 12) | Symptomatic (N = 10) | p-value | |
|---|---|---|---|---|
| No. female (%) | 9 (45%) | 8(67%) | 4 (40%) | 0.50 |
| Education, y | 14.4 (2.6) | 15.7 (2.1) | 14.3 (2.5) | 0.31 |
| Age at DTI scan, y | 49.1 (15.3) | 36.5 (7.3) | 54.2 (11.7) | <0.001a |
| MMSE | 29.4 (1.4) | 29.8 (0.4) | 20.2 (11.3) | <0.001b |
| CDR plus NACC FTLD SOB | 0.2 (0.6) | 0.1 (0.2) | 11.6(7.8) | <0.001b |
| DRS total MOANS | 11.6 (2.6) | 14.0 (1.8) | 5.2 (2.9) | <0.001b |
| No. of longitudinal subcohort (%) | 10 (50%) | 10 (83%) | 6 (60%) | 0.58 |
| No. DTI scans | 2.5 (0.7) | 3.2 (1.1) | 4.3 (1.8) | 0.08c |
| Follow-up, y | 4.0 (0.7) | 3.9 (0.6) | 3.4 (0.8) | 0.12 |
Data shown are n (%) or median (range).
p-values are from Fisher’s exact test or Kruskal-Wallis rank sum Test followed by Wilcoxon rank sum test.
Key: DTI, diffusion tensor image; MMSE, Mini-Mental State Examinations; CDR, Clinical Dementia Rating; NACC, National Alzheimer Coordinating Center; FTLD, fronto-temporal lobar degeneration; DRS, dementia rating scale; MOANS, Mayo’s Older Americans Normative Studies.
a
Asymptomatic is statistically different from other groups.
b
Symptomatic is statistically different from other groups.
c
All groups are statistically different from each other.