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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neurobiol Aging. 2019 Aug 15;83:54–62. doi: 10.1016/j.neurobiolaging.2019.08.011

Table 2.

Entorhinal WM multiple regression analysis testing the relationship between entorhinal FA and MD values with estimate or actual proximity to symptom onset in MAPT mutation carriers

FA MD
Est (95% CI) p R2 Est (95% CI) p R2
Intercept 0.15 (0.13, 0.17) <0.001 0.48 8165 (7103, 9226) <0.001 0.60
Time from onset −0.002 (−0.0035, −0.0007) 0.006 −8 (−100, 83) 0.85
Symptomatic 0.015 (−0.02, 0.05) 0.40 177 (−1663, 2016) 0.84
Symptomatic × time from onset 176 (34,317) 0.02

For FA, model includes only time from onset and group (MAPT mutation carriers) because there is no difference between asymptomatic and symptomatic MAPT mutation carriers. For MD, models include time from onset, group (symptomatic compared to asymptomatic MAPT mutation carriers) and interaction between time from onset and group.

Key: FA, fractional anisotropy; MAPT, microtubule-associated protein tau; MD, mean diffusivity; WM, white matter.