Table 1.
ALK Mutations in Pre- and Post-Lorlatinib Plasma Specimens
| Patient | Pre-Lorlatinib Plasma ALK Mutations | Post-Lorlatinib Plasma ALK Mutations |
|---|---|---|
| MGH9200 | L1196M | L1196M*, G1202R* |
| MGH9035 | G1202R, L1196M, V1180L | G1202R*, L1196M*, C1156Y |
| MGH9118 | D1203N | D1203N, G1123D |
| MGH9158 | L1196Q^, L1196M^, G1202R^ | L1196M |
| MGH087 | G1202R | G1202R |
| MGH9185 | G1202R | I1171N, D1203N |
| MGH9027 | I1171N | I1171N, D1203N |
| MGH059 | E1210K*, I1171N, V1180L, L1196M* | E1210K*, L1196M* |
| MGH9213 | L1196M | L1196M*, D1203N* |
| MGH990 | G1202R, I1171N | I1171N, D1203N |
| MGH9212 | I1171S, F1174L | I1171S, G1269A |
| MGH919 | G1202R*, L1196M* | G1202R*, L1196M* |
| MGH9176 | G1202R | G1202R |
| MGH915 | None | None |
| MGH964 | None | None |
Blue=mutation only seen in pre-lorlatinib specimen; Red=mutation only seen in post-lorlatinib specimen
*
ALK mutations occurred in cis
^
ALK mutations occurred in trans