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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Clin Cancer Res. 2019 Aug 28;25(22):6700–6708. doi: 10.1158/1078-0432.CCR-19-1231

Table 1 |.

Association between chromosome 5p15.33 locus and stroke among survivors from the St. Jude Lifetime Cohort (SJLIFE) study exposed to cranial radiation therapy

SNP BP EA NEA SJLIFE Europeans exposed to CRT (Discovery sample) SJLIFE Africans exposed to CRT (Replication sample)
EAFaff EAFnon-aff HR (95% CI) P EAFaff EAFnon-aff HR (95% CI) P
rs112896372 3756587 C T 0.27 0.16 2.55 (1.85–3.51) 1.42×10−8 0.23 0.13 3.05 (1.10–8.50) 0.034
rs79103129 3760131 A G 0.27 0.16 2.50 (1.82–3.44) 2.24×10−8 0.05 0.04 1.43 (0.25–7.99) 0.688
rs4391171 3760305 C G 0.27 0.16 2.50 (1.82–3.44) 2.24×10−8 0.05 0.04 1.43 (0.25–7.99) 0.688
rs17652293 3760914 G C 0.27 0.16 2.50 (1.82–3.44) 2.24×10−8 0.05 0.04 1.43 (0.25–7.99) 0.688
rs35710183 3753773 C T 0.28 0.17 2.36 (1.72–3.23) 1.13×10−7 0.05 0.04 1.43 (0.25–7.99) 0.688

Genomic positions are shown relative to GRCh38 (hg38); EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; EAFaff, EAF in survivors with stroke; EAFnon-aff, EAF in stroke-free survivors; HR, hazard ratio; CI, confidence interval; SJLIFE European-descent discovery sample (116 survivors with and 570 without stroke); SJLIFE African-descent replication sample (20 survivors with and 70 without stroke)