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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Clin Cancer Res. 2019 Aug 28;25(22):6700–6708. doi: 10.1158/1078-0432.CCR-19-1231

Table 2 |.

Association between chromosome 5p15.33 locus and stroke among independent survivors from the St. Jude Lifetime Cohort (SJLIFE) study not exposed to cranial radiation therapy (CRT) and in the UK Biobank participants

SNP BP EA NEA SJLIFE European-descent survivors not exposed to CRT (Independent dataset 1) SJLIFE African-descent survivors not exposed to CRT (Independent dataset 2) UK Biobank European males (Independent dataset 3)
EAFaff EAFnon-aff HR (95% CI) PCOX EAFaff EAFnon-aff HR (95% CI) PCOX EAFaff EAFnon-aff OR (95% CI) PLOGISTIC
rs112896372 3756587 C T 0.25 0.18 1.54 (0.99–2.39) 0.055 0.20 0.15 1.88 (0.60–5.88) 0.283 0.18 0.18 1.0012 (0.9999–1.0024) 0.042
rs79103129 3760131 A G 0.25 0.18 1.53 (0.99–2.37) 0.059 0.07 0.04 1.81 (0.28–11.87) 0.536 0.18 0.18 1.0012 (0.9999–1.0024) 0.039
rs4391171 3760305 C G 0.25 0.18 1.53 (0.99–2.38) 0.058 0.07 0.03 1.82 (0.28–11.87) 0.536 0.18 0.18 1.0012 (0.9999–1.0024) 0.039
rs17652293 3760914 G C 0.25 0.18 1.53 (0.99–2.38) 0.058 0.07 0.03 1.82 (0.28–11.87) 0.536 0.18 0.18 1.0012 (0.9999–1.0024) 0.040
rs35710183 3753773 C T 0.25 0.18 1.51 (0.98–2.32) 0.061 0.07 0.04 1.79 (0.27–11.77) 0.545 0.18 0.18 1.0014 (0.9998–1.0025) 0.022

Genomic positions are shown relative to GRCh38 (hg38); EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; EAFaff, EAF in survivors with stroke; EAFnon-aff, EAF in stroke-free survivors; HR, hazard ratio; OR, odds ratio; CI, confidence interval; PCOX, p-value from Cox regression; PLOGISTIC, p-value from logistic regression; Independent dataset 1 (60 survivors with 1581 without stroke); Independent dataset 2 (15 survivors with and 301 without stroke); Independent dataset 3 (2933 male stroke cases and 164055 male controls from the UK Biobank)