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. 2019 Nov 16;19:301. doi: 10.1186/s12935-019-1018-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MiR-140-5p regulated SACC-83 and SACC-LM cancer cell progression via targeting survivin. a, b CCK-8 assay, c colony formation assay, d transwell invasion assay respectively determined cell proliferation, growth and invasion of SACC-83 and SACC-LM cells after being treated with 100 nM YM-155 or normal medium (NC). e Flow cytometry and f caspase-3 activity assay respectively determine cell apoptotic rates and caspase-3 activity of SACC-83 and SACC-LM cells after being treated with 100 nM YM-155 or normal medium (NC). g qRT-PCR determined survivin mRNA expression levels in SACC-83 and SACC-LM cells after being transfected with pcDNA3.1 or pcDNA3.1-survivin. h, i CCK-8 assay, j colony formation assay, k transwell invasion assay respectively determined cell proliferation, growth and invasion of SACC-83 and SACC-LM cells after being co-transfected with mimics NC + pcDNA3.1, miR-140-5p mimics + pcDNA3.1 or miR-140-5p mimics + pcDNA3.1-survivin. f Flow cytometry and g caspase-3 activity assay respectively determine cell apoptotic rates and caspase-3 activity of SACC-83 and SACC-LM cells after being co-transfected with mimics NC + pcDNA3.1, miR-140-5p mimics + pcDNA3.1 or miR-140-5p mimics + pcDNA3.1-survivin. N = 3. Significant difference between treatment groups were indicated as *P < 0.05 and **P < 0.01