Fig. 3.

Comparative pathology of the bone tumor microenvironment in bone-related tumors. Tumor cells control their bone microenvironment differently, depending on the tumor type and the tumor-derived factors. Consequently, bone niches respond with different signal activations. The figure was produced using Servier Medical Art on www.servier.com with permission. a Breast cancer bone metastasis. b Prostate cancer bone metastasis. c Osteosarcoma. d Multiple myeloma. e Oral squamous cell carcinoma. f Giant cell tumor of the bone