TABLE 1.
Multivariable Cox Regression Predicting Overall Survival Using the Retrospective International Study of Cancers of the Urothelial Tract Cohort
| Covariate | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|
| Age | 1.01 | 0.98-1.04 | .405 | 1.01 | 0.98-1.04 | .589 | 1.01 | 0.98-1.04 | .490 |
| Sex | |||||||||
| Female | 1 | Reference | 1 | Reference | 1 | Reference | |||
| Male | 0.98 | 0.54-1.79 | .948 | 1.03 | 0.56-1.87 | .931 | 1.00 | 0.54-1.83 | .990 |
| CCI | 1.00 | 0.86-1.18 | .968 | ||||||
| 0 | 1 | Reference | 1 | Reference | |||||
| 1 | 1 | Reference | 1.02 | 0.30-3.42 | .977 | 0.88 | 0.26-2.95 | .831 | |
| ≥2 | 0.79 | 0.24-2.64 | .701 | 1.05 | 0.61-1.83 | .853 | 1.03 | 0.59-1.80 | .916 |
| Year of diagnosis | 1.05 | 0.60-1.84 | .859 | 0.98 | 0.84-1.15 | .830 | 1.00 | 0.85-1.17 | .973 |
| cT stage | |||||||||
| 2 | 1 | Reference | 1 | Reference | 1 | Reference | |||
| 3 | 1.66 | 0.98-2.83 | .060 | 1.47 | 0.86-2.51 | .156 | 1.61 | 0.95-2.75 | .079 |
| 4 | 1.45 | 0.42-5.04 | .562 | 0.85 | 0.25-2.87 | .799 | 1.31 | 0.37-4.63 | .673 |
| Surgical margin status | |||||||||
| Negative | 1 | Reference | 1 | Reference | 1 | Reference | |||
| Positive | 1.39 | 0.66-2.93 | .387 | 1.48 | 0.70-3.13 | .311 | 1.38 | 0.65-2.91 | .397 |
| pN stage | |||||||||
| 0 | 1 | Reference | 1 | Reference | 1 | Reference | |||
| ≥1 | 1.25 | 0.67-2.33 | .477 | 1.52 | 0.82-2.80 | .181 | 1.26 | 0.68-2.34 | .465 |
| pDS | |||||||||
| Absent | 1 | Reference | |||||||
| Present | 0.19 | 0.08-0.44 | <.001 | ||||||
| pCR | |||||||||
| Absent | 1 | Reference | |||||||
| Present | 0.11 | 0.03-0.47 | .003 | ||||||
| Response | |||||||||
| Absent | 1 | Reference | |||||||
| Downstaging | 0.35 | 0.13-0.93 | .035 | ||||||
| pCR | 0.09 | 0.02-0.38 | .001 | ||||||
| C index, % | 73.2 | 69.5 | 73.7 | ||||||
| P from Schoenfeld test | .3 | .5 | .1 |
Abbreviations: CCI, Charlson Comorbidity Index; HR, hazard ratio; pCR, pathologic complete response; pDS, pathologic downstaging.