TABLE 2.

Multivariable Cox Regression Predicting Overall Survival Using the National Cancer Database

Covariate	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age	1.03	1.02-1.03	<.001	1.03	1.02-1.04	<.001	1.03	1.02-1.03	<.001
Sex
Female	1			1			1
Male	0.96	0.83-1.12	.635	0.99	0.85-1.15	.854	0.97	0.83-1.13	.652
CCI
0	1			1			1
1	1.19	1.02-1.39	.028	1.20	1.03-1.40	.021	1.20	1.02-1.40	.025
2	1.34	1.01-1.79	.043	1.28	0.96-1.71	.088	1.31	0.99-1.75	.063
Year of diagnosis	0.94	0.91-0.97	<.001	0.94	0.91-0.97	<.001	0.94	0.91-0.97	<.001
cT stage
2	1			1			1
3	1.42	1.19-1.70	<.001	1.22	1.02-1.46	.027	1.37	1.14-1.64	.001
4	1.46	1.19-1.79	<.001	1.23	1.01-1.50	.043	1.39	1.13-1.71	.002
Surgical margin status
Negative	1			1			1
Positive	1.88	1.54-2.29	<.001	2.00	1.64-2.44	<.001	1.87	1.53-2.28	<.001
pN stage
0	1			1			1
1	1.82	1.48-2.23	<.001	2.23	1.83-2.72	<.001	1.83	1.49-2.24	<.001
2-3	2.66	2.24-3.17	<.001	3.22	2.72-3.81	<.001	2.68	2.25-3.19	<.001
pDS
Absent	1
Present	0.37	0.31-0.45	<.001
pCR
Absent				1
Present				0.25	0.18-0.35	<.001
Response
Absent							1
Downstaging							0.49	0.40-0.61	<.001
pCR							0.21	0.14-0.29	<.001
C index, %		71.7			70.4			72
P from Schoenfeld test		.13			.24			.13

Abbreviations: CCI, Charlson Comorbidity Index; HR, hazard ratio; pCR, pathologic complete response; pDS, pathologic downstaging.