Table 1.
GO term enrichment analysis for proteins that significantly drop in abundance in rapamycin treated cells (significance = P value <0.05 (two-tailed t-test with unequal variance) and fold change >2 standard deviations from the mean fold change). The top 5 enriched GO terms for biological processes, are presented.
| enriched GO term | fold enrichment | P value |
|---|---|---|
| CD8+ TCR | ||
| GO:0007049~cell cycle | 6 | 1.7 x 10-35 |
| GO:0051301~cell division | 7 | 5.5 x 10-35 |
| GO:0007067~mitotic nuclear division | 8 | 6.4 x 10-31 |
| GO:0007059~chromosome segregation | 10 | 6 x 10-14 |
| GO:0007018~microtubule-based movement | 12 | 1.2 x 10-9 |
| CD4+ TCR | ||
| GO:0006260~DNA replication | 10 | 1.2 x 10-12 |
| GO:0007049~cell cycle | 3 | 6.5 x 10-8 |
| GO:0006270~DNA replication initiation | 14 | 2.9 x 10-4 |
| GO:0006974~response to DNA damage | 2 | 8.5 x 10-4 |
| GO:0051726~regulation of cell cycle | 5 | 1.2 x 10-3 |
| CTL | ||
| GO:0006636~unsaturated fatty acid biosynth | 35 | 1.3 x 10-4 |
| GO:0006633~fatty acid biosynthetic process | 10 | 2.3 x 10-4 |
| GO:0006629~lipid metabolic process | 3 | 1.0 x 10-3 |
| GO:0030154~cell differentiation | 3 | 1.3 x 10-3 |
| GO:0016239~regulation of macroautophagy | 14 | 2.3 x 10-3 |
| TH1 | ||
| GO:0016126~sterol biosynth process | 12 | 9.3 x 10-5 |
| GO:0008202~steroid metabolic process | 6 | 6.2 x 10-4 |
| GO:0006695~cholesterol biosynth process | 11 | 7.9 x 10-4 |
| GO:0006694~steroid biosynthetic process | 7 | 8.2 x 10-4 |
| GO:0035455~response to interferon-alpha | 18 | 1.1 x 10-3 |