Table 3. The relationships between metal concentrations and total and allergen-specific IgEs.

Metal concentration median (25th, 75th)	Total IgE, IU/mL			Egg white-specific IgE, UA/mL			HDM-specific IgE, UA/mL
	Low (≤173; n = 11,133)	High (>173; n = 3,275)	P valuea	Low (<0.35; n = 14,260)	High (≥0.35; n = 148)	P valuea	Low (<0.35; n = 7,606)	High (≥0.35; n = 6,802)	P valuea
Cd	0.66 (0.50, 0.90)	0.65 (0.49, 0.88)	0.059	0.66 (0.50, 0.90)	0.60 (0.47, 0.84)	0.018	0.66 (0.50, 0.90)	0.65 (0.49, 0.90)	0.454
Pb	5.91 (4.78, 7.40)	5.99 (4.81, 7.49)	0.402	5.93 (4.79, 7.43)	5.62 (4.63, 7.35)	0.274	5.98 (4.80, 7.46)	5.88 (4.77, 7.39)	0.016
Hg	3.63 (2.57, 5.13)	3.58 (2.53, 5.12)	0.732	3.62 (2.56, 5.12)	3.64 (2.43, 5.41)	0.971	3.63 (2.58, 5.19)	3.61 (2.54, 5.09)	0.240
Se	169 (157, 182)	169 (157, 183)	0.526	169 (157, 182)	170 (157, 188)	0.389	169 (158, 183)	169 (157, 182)	0.045
Mn	15.2 (12.5, 18.5)	15.2 (12.6, 18.4)	0.952	15.2 (12.5, 18.5)	16.0 (12.7, 19.1)	0.320	15.2 (12.5, 18.5)	15.2 (12.6, 18.5)	0.683

Metal concentration median (25th, 75th)	JCP-specific IgE, UA/mL			Animal dander-specific IgE, UA/mL			Moth-specific IgE, UA/mL
	Low (<0.35; n = 6,453)	High (≥0.35; n = 7.955)	P valuea	Low (<0.35; n = 11,438)	High (≥0.35; n = 2,970)	P valuea	Low (<0.35; n = 10,331)	High (≥0.35; n = 4,077)	P valuea
Cd	0.66 (0.50, 0.91)	0.66 (0.49, 0.89)	0.308	0.66 (0.50, 0.90)	0.64 (0.48, 0.88)	0.003	0.66 (0.49, 0.90)	0.66 (0.50, 0.90)	0.574
Pb	5.92 (4.77, 7.43)	5.94 (4.79, 7.43)	0.837	5.93 (4.78, 7.43)	5.93 (4.79, 7.42)	0.594	5.90 (4.77, 7.41)	6.00 (4.81, 7.46)	0.105
Hg	3.48 (2.47, 4.91)	3.76 (2.64, 5.28)	<0.001	3.65 (2.58, 5.16)	3.52 (2.50, 5.02)	0.006	3.64 (2.58, 5.13)	3.58 (2.50, 5.12)	0.237
Se	168 (156, 182)	170 (158, 183)	<0.001	169 (157, 183)	168 (157, 182)	0.024	169 (157, 183)	169 (157, 182)	0.574
Mn	15.2 (12.5, 18.5)	15.2 (12.5, 18.5)	0.797	15.2 (12.6, 18.5)	15.1 (12.3, 18.5)	0.056	15.2 (12.6, 18.5)	15.1 (12.5, 18.4)	0.097

IgE, immunoglobulin E.

^aP values were obtained using Welch’s t-test with natural log transformed values.