Table 4. Results of multivariable analysis in the relationship between quartile concentration of metals and allergen-specific IgEs.
| Quartile concentration of metals (ng/g) |
HDM-specific IgE, UA/mL | JCP-specific IgE, UA/mL | Animal dander-specific IgE, UA/mL | |||||||||
| Low (<0.35; n = 7,606) |
High (≥0.35; n = 6,802) |
OR (95% CI)a | P valuea | Low (<0.35; n = 6,453) |
High (≥0.35; n = 7,955) |
OR (95% CI)a | P valuea | Low (<0.35; n = 11,438) |
High (≥0.35; n = 2,970) |
OR (95% CI)a | P valuea | |
| Cd | ||||||||||||
| Q1 (≤0.495) | 1,841 | 1,754 | 1.00 (referent) | 1,586 | 2,009 | 1.00 (referent) | 2,797 | 798 | 1.00 (referent) | |||
| Q2 (0.496–0.657) | 1,924 | 1,674 | 0.92 (0.84–1.02) | 0.100 | 1,628 | 1,970 | 0.94 (0.85–1.04) | 0.228 | 2,831 | 767 | 0.98 (0.87–1.10) | 0.746 |
| Q3 (0.658–0.897) | 1,943 | 1,661 | 0.94 (0.85–1.04) | 0.225 | 1,570 | 2,034 | 1.04 (0.94–1.15) | 0.464 | 2,905 | 699 | 0.90 (0.80–1.02) | 0.097 |
| Q4 (≥0.898) | 1,898 | 1,713 | 1.04 (0.94–1.15) | 0.498 | 1,669 | 1,942 | 0.98 (0.89–1.09) | 0.747 | 2,905 | 706 | 0.94 (0.83–1.07) | 0.368 |
| Pb | ||||||||||||
| Q1 (≤4.78) | 1,866 | 1,734 | 1.00 (referent) | 1,623 | 1,977 | 1.00 (referent) | 2,860 | 740 | 1.00 (referent) | |||
| Q2 (4.79–5.92) | 1,855 | 1,736 | 1.00 (0.90–1.10) | 0.935 | 1,618 | 1,973 | 1.00 (0.91–1.11) | 0.953 | 2,850 | 741 | 0.99 (0.87–1.11) | 0.815 |
| Q3 (5.93–7.42) | 1,937 | 1,670 | 0.92 (0.84–1.02) | 0.103 | 1,591 | 2,016 | 1.06 (0.96–1.17) | 0.252 | 2,858 | 749 | 1.01 (0.90–1.14) | 0.870 |
| Q4 (≥7.43) | 1,948 | 1,662 | 0.91 (0.83–1.01) | 0.073 | 1,621 | 1,989 | 1.04 (0.94–1.15) | 0.407 | 2,870 | 740 | 0.99 (0.88–1.12) | 0.885 |
| Hg | ||||||||||||
| Q1 (≤2.55) | 1,858 | 1,726 | 1.00 (referent) | 1,754 | 1,830 | 1.00 (referent) | 2,801 | 783 | 1.00 (referent) | |||
| Q2 (2.56–3.61) | 1,926 | 1,680 | 0.91 (0.82–1.00) | 0.057 | 1,684 | 1,922 | 1.06 (0.96–1.18) | 0.214 | 2,845 | 761 | 0.93 (0.83–1.05) | 0.238 |
| Q3 (3.62–5.11) | 1,856 | 1,727 | 0.98 (0.89–1.08) | 0.734 | 1,543 | 2,040 | 1.23 (1.12–1.36) | <0.001 | 2,865 | 718 | 0.88 (0.78–0.99) | 0.031 |
| Q4 (≥5.12) | 1,966 | 1,669 | 0.86 (0.78–0.95) | 0.003 | 1,472 | 2,163 | 1.35 (1.22–1.49) | <0.001 | 2,927 | 708 | 0.81 (0.72–0.92) | 0.001 |
| Se | ||||||||||||
| Q1 (≤156) | 1,755 | 1,659 | 1.00 (referent) | 1,624 | 1,790 | 1.00 (referent) | 2,680 | 734 | 1.00 (referent) | |||
| Q2 (157–168) | 1,878 | 1,719 | 1.00 (0.90–1.10) | 0.951 | 1,617 | 1,980 | 1.15 (1.04–1.27) | 0.008 | 2,813 | 784 | 1.06 (0.94–1.19) | 0.355 |
| Q3 (169–181) | 1,948 | 1,663 | 0.91 (0.82–1.01) | 0.063 | 1,593 | 2,018 | 1.17 (1.06–1.30) | 0.002 | 2,912 | 699 | 0.88 (0.78–1.00) | 0.046 |
| Q4 (≥182) | 2,025 | 1,761 | 0.94 (0.85–1.04) | 0.233 | 1,619 | 2,167 | 1.26 (1.14–1.39) | <0.001 | 3,033 | 753 | 0.95 (0.84–1.07) | 0.414 |
| Mn | ||||||||||||
| Q1 (≤12.4) | 1,856 | 1,628 | 1.00 (referent) | 1,550 | 1,934 | 1.00 (referent) | 2,711 | 773 | 1.00 (referent) | |||
| Q2 (12.5–15.1) | 1,924 | 1,704 | 1.01 (0.92–1.12) | 0.793 | 1,666 | 1,962 | 0.97 (0.87–1.07) | 0.494 | 2,900 | 728 | 0.87 (0.77–0.98) | 0.024 |
| Q3 (15.2–18.4) | 1,907 | 1,754 | 1.03 (0.94–1.14) | 0.519 | 1,614 | 2,047 | 1.03 (0.93–1.14) | 0.594 | 2,941 | 720 | 0.83 (0.74–0.94) | 0.002 |
| Q4 (≥18.5) | 1,919 | 1,716 | 1.01 (0.92–1.12) | 0.794 | 1,623 | 2,012 | 1.02 (0.92–1.13) | 0.681 | 2,886 | 749 | 0.90 (0.79–1.01) | 0.070 |
IgE, immunoglobulin E.
aOdds ratios and corresponding 95% confidence intervals and P values were obtained using multivariable logistic regression analysis adjusted for age, BMI, allergic diseases (asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergy, drug allergy), smoking during pregnancy, smoking habits of partner, alcohol consumption during pregnancy, owning pets, month of T1 blood sampling, and geographic region.